Initial fuel possibilities for the Thorium Molten Salt Reactor

The Generation IV International Forum placed six reactors as priority for research and development to compensate for the world\u27s increasing energy demands. Among the six were Molten Salt Reactors (MSRs). These reactors utilize the Th/233U fuel cycle using molten fluoride or chloride salts as coolants. MSRs also have the possibility to use other fissile fuels especially with the first fleet of reactors given the low amount of Uranium-233 available commercially. With the possibility of diverting from using 233U initially, the research presented here will benchmark 233U as a main fuel for MSRs using the Thorium Molten Salt Reactor (TMSR) designed by Billebaud Annick and her team at the Laboratory for Subatomic Particles and Cosmology in France. Uranium-235 and Plutonium-239 will then be tested as suitable initial fuels for the first fleet of TMSRs. These fuels will be compared to the reference data based on neutron flux spectra and breeding capabilities. --Abstract, page iii

The Cytochrome P450 Inhibitor, Ketoconazole, Inhibits Oxidized Linoleic Acid Metabolite-Mediated Peripheral Inflammatory Pain

BACKGROUND: Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if the OLAMs contribute to the peripheral activation of this receptor during tissue inflammation. In the present study, we evaluated whether the OLAM system is activated during inflammation and whether cytochrome P450 enzymes mediate OLAM contributions to heat hyperalgesia using the complete Freund’s adjuvant (CFA) model of inflammation. RESULTS: Our results demonstrate that the intraplantar (ipl) injection of anti-OLAM antibodies significantly reversed CFA-induced heat hyperalgesia. Moreover, application of lipid extracts from inflamed rat skin to cultured sensory neurons triggered a significant release of iCGRP that is blocked by co-treatment with I-RTX, a TRPV1 antagonist. To determine the role of CYP enzymes in mediating OLAM effects, we used a broad spectrum CYP inhibitor, ketoconazole. Pretreatment with ketoconazole inhibited the release of TRPV1 agonists in lipid extracts from inflamed skin and significantly reversed CFA-induced heat hyperalgesia by a peripheral mechanism of action. Moreover, the ipl injection of linoleic acid to rats 24 hr after CFA evoked spontaneous nocifensive behaviors that were significantly reduced by capsazepine, by knockout of the TRPV1 gene, or by pretreatment with either anti-OLAM antibodies or ketoconazole. CONCLUSIONS: Taken together, our data suggests that OLAMs contribute to inflammatory nociception in the periphery and that cytochrome P450 enzymes play a crucial role in mediating OLAM contributions to inflammatory heat hyperalgesia

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells

The interaction between a T cell and an antigen-presenting cell (APC) can trigger a signaling response that leads to T cell activation. Prior studies have shown that ligation of the T cell receptor (TCR) triggers a signaling cascade that proceeds through the coalescence of TCR and various signaling molecules (e.g., the kinase Lck and adaptor protein LAT [linker for T cell activation]) into microdomains on the plasma membrane. In this study, we investigated another ligand–receptor interaction (CD58–CD2) that facilities T cell activation using a model system consisting of Jurkat T cells interacting with a planar lipid bilayer that mimics an APC. We show that the binding of CD58 to CD2, in the absence of TCR activation, also induces signaling through the actin-dependent coalescence of signaling molecules (including TCR-ζ chain, Lck, and LAT) into microdomains. When simultaneously activated, TCR and CD2 initially colocalize in small microdomains but then partition into separate zones; this spatial segregation may enable the two receptors to enhance signaling synergistically. Our results show that two structurally distinct receptors both induce a rapid spatial reorganization of molecules in the plasma membrane, suggesting a model for how local increases in the concentration of signaling molecules can trigger T cell signaling

The Relationships between Fitness Assessments, Fitness Levels and Coronary Heart Disease Risk Markers in Police Officers

Given the physical nature of a position in law enforcement, the assessment of cardiovascular (CV) health as well as muscular strength and endurance is paramount to ensuring the safety of these personnel and the citizens they serve. The present study retrospectively examined correlations between several markers of CV and muscular fitness for 65 local police officers (8 female, average age 35.6 ± 9.0 yrs, height 70.5 ± 2.8 in, weight 91.8 ± 18.7 kg, VO2 33.0 ± 5.3 mL/kg/min) taken from their annual screening including a graded exercise test (GXT; Bruce protocol), pushups completed in 1 minute, situps completed in 1 minute, handgrip strength, body composition (through DEXA and circumference measures) and bloodwork. Maximal oxygen uptake (VO2max) was estimated using the Foster equation. Coronary heart disease risk (CHD risk) was calculated using the online NIH 10-year heart attack risk calculator, which uses age, gender, total cholesterol, HDL cholesterol, smoking status, and blood pressure status in its algorithm. Significance was determined using an alpha level of 0.05. Interestingly, there was no significant correlation between VO2max and CHD risk (p = 0.1851). Apart from risk markers included in the risk calculation, CHD risk was significantly correlated with waist-hip ratio (r = 0.24739), and LDL cholesterol (r = 0.39117). VO2max was significantly negatively correlated with fat mass (r = -0.51849), body fat percentage (%BF; r = -0.64297), total cholesterol (TC; r = -0.3371), and LDL cholesterol (r = -0.267). Positive correlations were found between VO2max and other measures of fitness such as pushups (r = 0.54274), situps (r = 0.3282), and handgrip strength (r = 0.32041). As for body composition measures, %BF was significantly positively correlated with TC (r = 0.30188), systolic blood pressure (r = 0.28795), LDL cholesterol (r = 0.26533), and fasting glucose (r = 0.26536), but negatively correlated with fitness markers such as pushups (r = -0.58599), situps (r = -0.43604), and handgrip strength (r = -0.32393). Lean mass was significantly correlated with handgrip strength (r = 0.71835), though not pushups, situps or VO2max. Waist circumference was significantly negatively correlated with HDL cholesterol (r = -0.39202). Additionally, 62 of the participants (7 female) completed both a 1.5 mile run and GXT, allowing for a comparison of a submaximal to a maximal fitness assessment of CV fitness. Time to complete 1.5 miles was significantly correlated to GXT VO2max, with a Pearson correlation coefficient of -0.79593. Overall, relationships found between health markers, fitness, and CHD risk in this sample were in line with previous research on CHD risk factors and the assessment of CV and muscular fitness

Lipid Profiles of American Collegiate Football Athletes in Response to Fall Preseason Camp

Recent studies show former football athletes, especially football linemen, to be at increased cardiovascular disease risk. However, the lipid profiles of American NCAA Football Bowl Subdivision (FBS) players in response to sport participation are currently unknown. PURPOSE: To quantify the effects of participation in fall preseason football training camp on the blood lipid profiles in NCAA FBS athletes. METHODS: Seated venous blood samples were drawn in the morning after an overnight fast from 51 football players (age = 20 ± 2 yr, weight = 232.8 ± 40.8 lb, height = 73.9 ± 2.6 in) and analyzed for total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HLD-C), and triglyceride (TG). Samples were obtained on two separate occasions corresponding to the beginning of fall preseason football camp, and again 16 days later near the end. Data were analyzed by paired t-test. RESULTS: See table, values are means ± SD, * = p ≤ 0.001. Measurement Time Lipid and Lipoprotein Concentrations (mg/dL) TC LDL-C HDL-C TG TC:HDL Ratio Beginning 158 ± 34 90 ± 24 54 ± 15 117 ± 50 3.02 ± 0.70 End 151 ± 35 92 ± 28 47 ± 11* 86 ± 41* 3.32 ± 0.84* CONCLUSION: Participation in fall preseason training camp significantly alters the traditional lipid profiles of Collegiate FBS athletes. These lipid changes suggest a proinflammatory state with high energy utilization, and are consistent with the hypothesis that LDL-C is necessary for the structural repair of damaged tissue

Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease

Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), where exposure to dietary antigen can be controlled, gluten-induced inflammation triggered a profound depletion of naturally occurring Vγ4+/Vδ1+ intraepithelial lymphocytes (IELs) with innate cytolytic properties and specificity for the butyrophilin-like (BTNL) molecules BTNL3/BTNL8. Creation of a new niche with reduced expression of BTNL8 and loss of Vγ4+/Vδ1+ IELs was accompanied by the expansion of gluten-sensitive, interferon-γ-producing Vδ1+ IELs bearing T cell receptors (TCRs) with a shared non-germline-encoded motif that failed to recognize BTNL3/BTNL8. Exclusion of dietary gluten restored BTNL8 expression but was insufficient to reconstitute the physiological Vγ4+/Vδ1+ subset among TCRγδ+ IELs. Collectively, these data show that chronic inflammation permanently reconfigures the tissue-resident TCRγδ+ IEL compartment in CeD

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Does ECG Predict Cardiac Hypertrophy in American-Style Football Athletes?

The accurate and cost effective identification of left ventricular (LV) hypertrophy is clinically relevant due to its association with cardiac mortality in the general population. PURPOSE: To determine if electrocardiographic (ECG) voltage criteria predicts LV mass measured with cardiac ultrasound in collegiate American-style football (ASF) players. METHODS: Over a 3-year period, standard resting, supine 12-lead ECG and echocardiographic (ECHO) procedures were performed on 76 collegiate ASF players first entering an NCAA Football Bowl Subdivision university as part of their preparticipation physical exams. Player demographics were: age=18±1 yr., height=186±7 cm, weight=100.1±22.0 kg, BMI=28.6±5.0 kg·m2, and BSA=2.24±0.25 m2. Linear regression was used to predict ECHO-derived LV mass and LV mass/BSA index from ECG precordial-lead voltage criteria [sum largest S (V1 or V2) + R (V5 or V6) ≥ 35 mm]. RESULTS: ECG voltage criteria did not significantly (p \u3e 0.05) predict ECHO LV mass (LV mass = -0.12x + 216.94, r = 0.024, R² = 0.0006), or LV mass/BSA index (LV mass/BSA = 0.3063x + 81.951, r = 0.17, R² = 0.0244). CONCLUSION: ECG precordial lead voltage was not clinically useful in diagnosing ECHO-derived LV hypertrophy in our sample of first-year collegiate ASF players. We suggest that new and more accurate algorithms for evaluating LV hypertrophy in ASF athletes be explored, possibly using demographic, body habitus, cardiovascular, and other ECG criteria